Powerups

Powerup	Description
Ankh of Life	Gives you 1 max health every time you open a chest. Unlock: Defeat the tier 5 boss. (Needs confirmation) Stacking: More health per chest opened.
Vigor Beetle	Killing enemies gives a very small amount of max health. Stacking: Higher chance to give the player more max health when killing an enemy.
Dracul's Blood	Melee attacks sap health from enemies hit. Stacking: More health is drained per hit.
Volcanic Bomb	Bullets randomly explode, dealing damage in a small radius. Unlock: Reach depth 5,000 without taking damage while equipped with TNT Sling. Stacking: Bigger explosions, more damage.
Punchy Fist	Randomly punch enemies with great force. Stacking: Fists do more damage (8 damage per stack). May also increase knockback.
Flying Bracer	Grants an additional jump. Stacking: One extra jump per stack.
Burstfire	Each stack will instantly shoot a second round of bullets. Unlock: Collect 2 or more Spreadshot with the Nailgun Stacking: More bullets!
Cluster of Iron	Bigger bullets, more damage. Stacking: further increased bullet size and damage.
Double Melee	Gives you an additional melee weapon, increasing damage and dig speed. Stacking: Adds another melee weapon each time.
Phoenix Pinion	Leaves a trail of fire. Stacking: Trail gets taller and does more damage.
Heart of Belial	Regenerates health over time. Unlock: Recover 1000 HP in a single run with Rex's passive ability. Stacking: Regenerates health faster.
Cyclops Skull	Increases accuracy and crit chance. Adds a laser sight to your weapon. Stacking: Adds a bigger chance of getting a crit.
Djinn's Zephyrhorn	Bolsters melee attack speed. Stacking: Makes swinging even faster.
Pylon of Frost	Freezes enemies in their tracks. Stacking: Increases slow.
Sullied Kirpan	Periodically throw knives. Stacking: Knives are thrown more often.
Wind Leaf	Run faster. Unlock: Defeat Giga Mechworm. Stacking: Runs even faster.
Missile Expansion	Randomly fires a missile. Stacking: More missiles more often.
Scattershot	Increases the number of projectiles your gun fires. also seems to decrease shot size and damage slightly, this effect doesn't seem to stack, also renders growth battery useless. Stacking: More projectiles are fired each stack.
Piercing Oculus	Attacks reduce armor. Stacking: More armor reduction.
Homesick Shard	Strikes nearby enemies with green shards. Stacking: Shards do more damage (3 per stack) and travel farther.
The Negotiators	Increases critical hit damage. Stacking: Increases crit damage further.
Toxic Flask	Adds a poison effect when you hit a enemy with your projectiles. Stacking: Adds more damage per tick.
Poofshroom	Emits cloud of poison on impact. Stacking: Increases cloud size and poison damage.
Tesla	Bullets have a chance to shock nearby enemies. Unlock: Kill an Electric Elite By knocking it off the edge. Stacking: Higher chance of shocking.
Hero's Blade	Shoots a sword (where you're aiming at) when at full health and using melee. Stacking: Sword does more damage.
Golem's Core	A shield that explodes after taking damage. Stacking: Shield absorbs more damage before exploding, deals more damage and has a shorter cooldown.
Aces	Chance to instantly kill enemy on critical hit. currently tends to lag the game when you hit a enemy with a sawblade CRITICAL. Stacking: Higher chance to kill.
Plague Scarab	Plagues enemies shot with infection that spreads to other enemies. Stacking: Higher chance to plague.
Beetle Barrage	Randomly unleashes an explosive swarm of beetles on impact. stacking: ???
Bomb Squad Armor	Increases armor and reflects damage. Stacking: Increases armor further.
Mole's Orchid	Destroyed terrain can sometimes spawn health. Stacking: Higher chance of health spawning.
Black Hole Box	Increases magnetic power. Stacking: Increases magnetic power further.
Tome of Secrets	Increases chance of random powerup drops. Unlock: Enter a cycle/loop. Stacking: Higher chance of drops.
Flash Bang	Has a chance to throw a grenade that stuns enemies Unlock: survive arena mode for 5 minutes Stacking: ???
Paralysis Curse	Critical hits inflict enemies with a paralyzing curse. Currently bugged and causes you to take damage over time Stacking: increases stun duration
Siren Harp	Stuns every enemy when you kill an elite enemie. Stacking: increases stun duration
Giga Drill Bit	Increases digging power. Stacking: further increases digging power.
Doppelganger Torch	Creates a ghostly clone when you take damage.  Clone appears as a transparent outline of your character and shoots several projectiles that seek the closest enemy. Stacking: Increases number of projectiles spawned.
Resplendent Vial	A serum that increases gem discovery. Unlock: Kill a wall golem. (Needs confirmation) Stacking: further increases amount of gems dropped by enemies.
Growth Battery	Charges your bullets while not shooting. Stacking: ???
Pilfer Engine	Reduces the cost of chests. Stacking: further reduces cost of chests.
Money Shot	Increases damage based on gems held. Unlocked by having 20000 gold. Stacking: ???
Phantom Missile	Dying enemies release vengeful spirits. Stacking: ???
Philospher's Stone	Picking up gems grants health Stacking: ???
C4	Some enemies explode on death. Stacking: ???
Thorny Gem	Large gems deal damage to enemies Stacking: ???
Clump of Moss	Critical hits grant health. Stacking: more health gained per crit.